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Ovarian, breast cancers: New, targeted therapy - CBS News In most breast and ovarian cancers that have been studied from carriers of pathogenic variants, deletion of the normal allele results in loss of all function, leading to the classification of BRCA1 and BRCA2 as tumor suppressor genes. There was no reduction in risk of invasive ER-negative breast cancer. Popular on CBS News. An ovarian cancer symptom index for predicting the presence of cancer was evaluated in 75 cases and high-risk controls carriers of BRCA pathogenic variants or women with a strong family history of breast and ovarian cancer. It is likely that other genetic factors contribute to the etiology of some of these cancers. The association between HRT and breast cancer risk among women with a family history of breast cancer has not been consistent; some studies suggest risk is particularly elevated among women with a family history, while others have not found evidence for an interaction between these factors. Both males and females can inherit and transmit an autosomal dominant cancer predisposition gene.
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